filling of soft gelatin capsules slideshare 2

Solid dosage forms (capsules)

Methods of filling the hard gelatin capsules • The capsules can be filled either by hand or by a semi- automatic device or by an automatic filling machine • Capsule filling machine (Hand operated) It consists of:- 1 A bed having 200-300 holes 2 A loading tray having 200-300 holes 3 A powder tray 4 A pin plate having 200-300 pins 5 A sealing plate having a rubber top 6 A

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Hard gelatin capsules ppt B

Most capsules of both types are intended to be swallowed whole however some soft gelatine capsules are intended for rectal or vaginal insertion as suppositories 4 4 Hard Gelatin Capsule:Hard Gelatin Capsule: The hard gelatin capsule consists of two pieces in the form of cylinders closed at one end The shorter piece is called the cap

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Capsules

The rotary die process (1933 R P Scherer) more efficient and productive Manufacturing of Soft Gelatin Capsules 1) Liquid gelatin is formed into two ribbons 2) The two ribbons are brought together 3) Metered fill material is injected between the ribbons 4) These pockets of fill-containing gelatin are sealed 92 Girish B KLEUCOP Belgaum

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Hard Gelatin Capsules: Formulation and Manufacturing

Some high-speed capsule-filling machines form a plug of the powder before filling into the capsule In cases where plug formation is required for encapsulation some level of compactibility of the powder is needed difference between hard gelatin capsule and soft gelatin capsule slideshare raw material for hard gelatin capsules

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Hard gelatin capsules ppt B

Most capsules of both types are intended to be swallowed whole however some soft gelatine capsules are intended for rectal or vaginal insertion as suppositories 4 4 Hard Gelatin Capsule:Hard Gelatin Capsule: The hard gelatin capsule consists of two pieces in the form of cylinders closed at one end The shorter piece is called the cap

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3 Ways to Fill Pill Capsules

Apr 30 2020Use gelatin capsules if you don't have dietary restrictions Gelatin capsules are made from beef gelatin You won't taste any beef flavor though! They tend to be slightly cheaper than vegetarian capsules Check a health food store for gelatin capsules or buy them online

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dx doi/10 14227/DT120205P6 A Comparison of

The USP Apparatus 2 and Apparatus 4 were compared for dissolution of soft gelatin capsule formulations of a poorly water-soluble amine drug Using an acidic medium with added surfactant both apparatuses gave similar dissolution profiles Apparatus 2 tended to give a faster rate of dissolu-tion but Apparatus 4 was better able to distinguish

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MANUFACTURING PROCESS OF SOFT GELATIN CAPSULE (Part I

Manufacturing process of soft gelatin process divided into some steps there are: 1 Gelatin Preparation 2 Material (Fill) Preparation 3 Encapsulation 4 Drying 5 Inspection 6 Polishing 7 Packaging Gelatin Preparation Raw granular gelatin is mixed with glycerine and water Coloring agent can also be added at this stage

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Tablets Capsules January 2007

Furthermore soft gelatin may expose the fill material to more oxygen than a hard capsule would because the plas-ticizers in soft gelatin create channels that are larger than those in hard gelatin See Figure 2 Greater exposure to air increases the potential for oxidizing (degrading) the fill material In addition to an inherently lower oxidation

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Ppt of Manufacturing And Evaluation of Capsules

17 SOFT GELATIN CAPSULE Definition:- Soft Gelatin capsules are one piece hermetically sealed soft gelatin shells containing a liquid a suspension or a semisolid Soft gelatin is mainly composed of gelatin plasticizers preservative colouring and

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Capsules (Pharmaceutics)

Excipients used in the filling of capsules: Excipients used in the filling of capsules While filling solid medicaments in a powder form into the body of a hard gelatin capsule the following additives are included in the formulation: DILUENTS The diluent is needed in certain cases where the quantity of the medicament is too small in bulk to get it filled in the smallest available capsule

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Capsules

Capsules Definition: Capsules are solid dosage forms in which one or more drugs and inert substances are enclosed within a small shell or container generally prepared from a suitable form of gelatin Gelatin capsule shells may be hard or soft depending on their composition Capsules are of 2 types 1- Hard Gelatin Capsules 2- Soft Gelatin

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Capsule's

1 Composition of the shell The basic component of soft gelatin shell is gelatin however the shell has been plasticize The ratio of dry plasticizer to dry gelatin determines the "hardness" of the shell and can vary from 0 3-1 0 for very hard shell to 1 0-1 8 for very soft shell Up to 5% sugar may be included to give a "chewable" quality to the shell The residual shell moisture content of finished

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Hard gelatin capsules ppt B

Most capsules of both types are intended to be swallowed whole however some soft gelatine capsules are intended for rectal or vaginal insertion as suppositories 4 4 Hard Gelatin Capsule:Hard Gelatin Capsule: The hard gelatin capsule consists of two pieces in the form of cylinders closed at one end The shorter piece is called the cap

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Filling two

Filling two-piece hard gelatin capsules with liquids Tablets Capsules MagazineThis article provides an overview of the benefits of filling two piece hard gelatin capsules with liquids It discusses formulation requirements compares two-piece hard capsules to softgels and offers strategies for liquid filling

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SOFT GELATIN CAPSULES

SOFT GELATIN CAPSULES --- Pgims - authorSTREAM Presentation Slide 8: 8 Up to 5% sugar is added to make shell chewable 9 1% Fumaric acid is added to increase acid solubility 10 0 15% Sulfur dioxide(so2) treatment is done to prevent the decomposition of gelatin 11 Preservatives like methyl paraben and propyl paraben added in conc of 2% 12 Iron content should not be

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Soft Gelatin Capsule Shell : Composition Formula and

A soft gel capsule is a one piece hermetically sealed soft gelatin shell containing a liquid a suspension or a semisolid referred to as a fill The soft gel shell is usually comprised of a film-forming material such as gelatin and a water-dispersible or water-soluble plasticizer (to impart flexibility) The soft gel shell could also include minor additives such as coloring agents flavors

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Soft Gelatin Capsules

Nov 27 2010Soft Gelatin Capsules 1 Mr Nitin M KadamMr Nitin M Kadam M Pharm [Pharmaceutics] nitkadamgmail 2 Introduction Advantages Disadvantages Shapes Of Capsules Anatomy Of Soft Gelatin Capsule The Nature Of Capsule Shell The Nature Of Capsule Content Encapsulation Plant Layout 3

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PPT

SOFT GELATIN CAPSULE Definition- Soft Gelatin capsules are one piece hermetically sealed soft gelatin shells containing a liquid a suspension or a semisolid Soft gelatin is mainly composed of gelatin plasticizers preservative colouring and opacifying agents flavoring agents and sugars 18 APPLICATION OF SOFT GELATIN CAPSULE The

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Capsule

Advantages of soft gelatin capsule:- 1) Soft gelatin capsules permit liquid medicament to be easily portable 2) Accuracy and uniformity of the dosage are predominant advantages with soft capsules Since the liquid fill is metered into individual capsule by a positive displacement pump

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Manufacture of Soft Gelatin Capsules

Soft gelatin capsules as defined in our previous "Soft Gelatin Capsules: Formulation and Manufacturing Considerations" are hermetically sealed one-piece capsules containing a liquid or a semisolid fill without a bubble of air or gas They are made from a more flexible plasticized gelatin film than hard gelatin capsules Soft gelatin capsules have gained popularity in the

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