diisodecyl phthalate uses for dogs

Risk Assessment Report Di

Risk Assessment Report Di-isodecyl phthalate (DIDP) (Apparatuses Containers and Packages) Food Safety Commission of Japan (FSCJ) April 2016 ABSTRACT FSCJ conducted a risk assessment of di-isodecyl phthalate (DIDP) (CAS No 68515-49-1 and CAS No 26761-40-0) for the revision of the standards and criteria for apparatuses containers and packages

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Acknowledgements

Diisodecyl phthalate (DIDP) An EFSA review of DIDP concluded that effects on liver reproduction and development are the critical end-points on which to base a risk assessment of DIDP A NOAEL of 33 mg/kg bw/day was identified for effects on offspring survival in multigenerational studies of rats and a NOAEL of 15 mg/kg bw/day was identified for liver effects in a repeated dose toxicity study

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1 2

Diisodecyl phthalate (DIDP) is assigned two CAS numbers: 26761-40-0 and 68515-49-1 The commercial product is a complex but not variable substance The liver was shown to be the target organ of toxicity in oral studies of rats and dogs Developmental toxicity and teratogenicity observed in rats (at doses below those maternally toxic in some studies) No reproductive toxicity observed in rats

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Study of Industrial Data on Candidate Chemicals for

----- EPA 560/5-78-002 June 1978 A STUDY OF INDUSTRIAL DATA ON CANDIDATE CHEMICALS FOR TESTING Contract No 68-01-4109 Research Request No 3 Project Officer: James Darr Prepared for Office of Toxic Substances U S Environmental Protection Agency Washington D C 20460 333 Ravenswood Ave • Menlo Park California 94025 (415) 326-6200 • Cable: STANRES Menlo Park •

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Dog Kennel Liners by G

WARNING This product can expose you to chemicals including - Vinyl chloride monomer Carbon black Ethyl acrylate Titanium dioxide Rutile (TiO2) 1 2-benzendikarboxylsyra di-C8-10-alkyl ester grenad Nickel antimony yellow rutile (C I Pigment Yellow 53) Quartz which are known to the State of California to cause cancer and/or Diisodecyl phthalate which is known to the State of California

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DI(2

This substance was considered by previous Working Groups in October 1981 (IARC 1982) March 1987 (IARC 1987) and February 2000 (IARC 2000) Since that time new data have become available and these have been incorporated into the Monograph and taken into consideration in the present evaluation

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Environment and Climate Change Canada

State of the Science Report Phthalate Substance Grouping 1 2-Benzenedicarboxylic acid diisononyl ester and 1 2-Benzenedicarboxylic acid di-C8-10-branched alkyl esters C9-rich (Diisononyl Phthalate DINP) Chemical Abstracts Service Registry Numbers 28553-12-0 and 68515-48-0 Environment Canada Health Canada August 2015

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DI(2

This substance was considered by previous Working Groups in October 1981 (IARC 1982) March 1987 (IARC 1987) and February 2000 (IARC 2000) Since that time new data have become available and these have been incorporated into the Monograph and taken into consideration in the present evaluation

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Identification and assessment of alternatives to selected

Diisodecyl phthalate (DIDP) is a common phthalate plasticiser used primarily to soften Polyvinyl chloride (PVC) The typical content of DIDP in flexible PVC products is between 25 and 50% (w/w) It has properties of volatility resistance heat stability and electric insulation and is typically used as a plasticiser for heat-resistant electrical cords leather for car interiors and PVC

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The legislation was previously agreed by the EU in 2005 (Directive 2005/84/EC) and sets a content limit of 0 1% weight/weight (w/w) of the plasticised material for DINP and another two phthalates diisodecyl phthalate (DIDP) and di-n-octyl phthalate (DnOP) for toys and child-care articles that can be placed in the mouth by children under three years of age

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The legislation was previously agreed by the EU in 2005 (Directive 2005/84/EC) and sets a content limit of 0 1% weight/weight (w/w) of the plasticised material for DINP and another two phthalates diisodecyl phthalate (DIDP) and di-n-octyl phthalate (DnOP) for toys and child-care articles that can be placed in the mouth by children under three years of age

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Opinion of the Scientific Panel on food additives

In a 13-week oral study in dogs liver changes were seen at higher dose levels with a lowest observed adverse effect level (LOAEL) of 77 mg/kg bw/day and 88 mg/kg bw/day for male and dogs respectively The Panel concluded that the NOAEL of 15 mg/kg bw/day from this study should be used in the risk assessment

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VRM Wire7 Vaccine Resistance Movement

'The offending chemical diisodecyl phthalate was found at 2 times the European limit Hong Kong officials said The government there has been routinely testing products with flavoring agents after products in Taiwan were found to contain plasticizers similar to but more toxic than the phthalate found in GSK's product the newspaper reports '

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Concerns About Phthalate Exposure Exposure to phthalates can occur by ingestion inhalation and through skin contact Plastic storage containers can contaminate foods and drinks We can breath dust that has come into contact with vinyl wallpaper mini-blinds

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NY State Senate Bill S7660

Optional services from the NY State Senate: Send me alerts for this bill I can unsubscribe at any time Learn more Create an account An account allows you to officially support or oppose key legislation sign petitions with a single click and follow issues committees and bills that matter to you

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Study of Industrial Data on Candidate Chemicals for

----- EPA 560/5-78-002 June 1978 A STUDY OF INDUSTRIAL DATA ON CANDIDATE CHEMICALS FOR TESTING Contract No 68-01-4109 Research Request No 3 Project Officer: James Darr Prepared for Office of Toxic Substances U S Environmental Protection Agency Washington D C 20460 333 Ravenswood Ave • Menlo Park California 94025 (415) 326-6200 • Cable: STANRES Menlo Park •

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1 2

Diisodecyl phthalate (DIDP) is assigned two CAS numbers: 26761-40-0 and 68515-49-1 The commercial product is a complex but not variable substance The liver was shown to be the target organ of toxicity in oral studies of rats and dogs Developmental toxicity and teratogenicity observed in rats (at doses below those maternally toxic in some studies) No reproductive toxicity observed in rats

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DI(2

This substance was considered by previous Working Groups in October 1981 (IARC 1982) March 1987 (IARC 1987) and February 2000 (IARC 2000) Since that time new data have become available and these have been incorporated into the Monograph and taken into consideration in the present evaluation

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